INITIAL SYMPTOMS AND LATE PRESENTATION OF HIV INFECTED PERSONS SEEN IN HIV CLINICS UYO, AKWA IBOM

Background: Recognition of HIV symptoms may be associated with the stage in which HIV infected persons, present at health facilities to seek care, this study aimed at describing the initial symptoms of People living with HIV (PLWHIV) and determine socio demographic characteristics associated with late presentation at the HIV clinics in Uyo. Methods: This was a cross-sectional descriptive study carried out on PLWHIV at initial visits to either of the two HIV clinics in Uyo. Data was collected using a pre-tested interviewer administered questionnaire, while CD4 and clinical stage were obtained from the patients’ folders. Result: A total of 166 respondents were recruited over a period of four months, 67% of them were females and significantly younger than the males (p value=0.0039). The proportion of late presenters was 60%. Secondary level of education predicted late presentation compared to primary level (OR 5.6 P value= 0.004). PLWHIV whose length of time after diagnosis were between 1 to 3 months and those above 1 year were less likely to present late compared to those that presented within 1 month of diagnosis (OR 0.18, P value 0.03; OR 0.86 P value < 0.0001 respectively). Those who had no perception of illness were not likely to present late (OR 0.6; p value <0.0001). Fever (OR 3.9; P value 0.025), rashes (OR 5.4 P value 0.002) defined late presentation Conclusion: With the high level of late presentation of PLWHIV to health facilities, Voluntary Counselling and Testing (


INTRODUCTION
Human Immunodeficiency Virus (HIV) infection is known as the most detrimental infectious disease, with over 36 million people already infected 1 globally; about 70% of people living with the virus 2 live in sub-Saharan Africa.In Nigeria about four million people are living with the virus, which makes Nigeria the country with second highest 3 burden of HIV in the world.The 2013 National HIV/AIDS and Reproductive Health survey reported a national prevalence of 3.4% and 6.8% for 4 Akwa Ibom State.Despite the availability of free voluntary counseling and testing many people are not aware of their serostatus.A report showed that about 50% of people living with HIV (PLWHIV) in 5 sub-Sahara Africa are not aware of their status.Quite often, the fear of stigma and discrimination prevents people from accessing HIV screening 6 service and even the asymptomatic PLWHIVs would prefer to wait till they show symptoms before accessing care.One of the determinants of treatment success, is the health status of the patient at the point of accessing care.Patients who present late for care are less likely to have good treatment outcomes, leading to high 7,8 mortality rate among them.In HIV infection, viral load increases when there is no treatment, which increases the risk of transmission and thus constitutes a huge threat to the society.Symptoms are described as a person's perception of an abnormal physical, emotional and cognitive state and as the main reason why patients seek for health 10 care.The symptoms at the point of initiating care are not specific and they vary among different individuals depending on their level of immunity 11,12 and the exposure to opportunistic infections.Symptoms of advanced disease include persistent fever, oral thrush, persistent diarrhea, persistent rashes, severe weight loss and others symptoms of 90% of all HIV positive individuals.There is no study seen in the literature that had described selfreported symptoms and status of PLWHIV at the point of accessing care in Nigeria.Determining the proportion of HIV positive patients who presented late in our clinics may help health professionals to plan for appropriate care and treatment of advanced disease, and help to advice the program managers in resource allocations.The aim of this study was to identify the common self-reported symptoms of HIV patients at the initial visit to the HIV clinics in our locale and the socio demographic factors associated with late presentation.This was a descriptive cross-sectional study of newly enrolled HIV positive patients, who presented in the HIV clinics of University of Teaching Hospital and St Luke Hospital, Anua.The minimum sample size calculated using the percentage of late presentation from a previous 18 study 67%, was adjusted to 165, based on 320, which was the estimated number of new patients seen over four months (71 and 9 new patients seen every month in SLHA and UUTH respectively).The adjusted sample size was proportionally allocated to UUTH and SLHA at a ratio of 1:8.All new patients who presented to both clinics were recruited consecutively over the period of four months, provided they gave informed written consent.However, patients with previous history of taking antiretroviral drugs and those with known history of tuberculosis, diabetes, hypertension and cancers were excluded from the study.Data were collected by trained research assistants (Nurses and HIV volunteers working in the clinics), using a pre-tested interviewer administered structured questionnaire taken from WHOQOL-

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HIV BRIEF tool, this study was a part of Quality of Life of HIV patients' study.The baseline CD4 count and the clinical staging of the patients were extracted from their folders as documented by the clinician after their enrolment into care.The data were entered, cleaned, verified and analyzed using Stata version 10.

The outcome variables
The clinical presentation was categorized into early and late using European Consensus Definition of Late Presentation.Early presentation was WHO Clinical stages 1 and 2 with CD4 above 350cells/ml, while late presentation was WHO Clinical stages 3 and 4 and /or CD4 count below 350cells/ml.The categorical variables were described using proportions while mean and standard deviation were used to summarize continuous variables.The proportions of the patients who presented with each symptoms was also determined.Chi square test was Recruitment into the study was voluntary and the decision not to participate did not affect their treatment in any way.The participants were interviewed individually within an enclosure in the clinics for privacy, names of the respondents were not documented on the questionnaire to ensure confidentiality.A written Informed consent was obtained from each respondent.used to determine association between variables while multivariate analysis was done for variables with p value< 0.

RESULTS
A total 166 respondents were successfully recruited for the study, out of which 67% (111) were females.
The respondents aged 18 to 58 years, with a mean ± SD of 31.9±8.9years.Forty-six percent of the respondents (77/166) were within age group 21-30 years and the females were significantly younger than the male (P=0.0039).A total of 116 (69.8%) had at least secondary level of education and more than 50% of them were living alone.The mean CD4 was 301.2 ± 16.3 cells/ml, these were similar in both sexes More than half (60.2%) of the respondents presented late to clinics for HIV care.About 57% presented within 1 month of being aware of their HIV serostatus.The median interval of presentation from the time of diagnosis was 3 weeks.At the time of presentation, less than one-third (29%) of them  1) At bivariate level, possible route of transmission and being ill, showed significant association with late presentation.The mean CD4 for the late presenters was 178.1 (14.2) cells/ml.(Table 2).At the multivariate analysis, secondary level of education, being ill and short length of time from the point of diagnosis were the predictors of late presentation (Table 3) Fever, cough and rashes were the most common symptoms at presentation, 21%, 18.7% and 16.9% respectively.Fever, rashes and frequent stooling were significantly associated with late presentation at the bivariate level with p value of 0.002, 0.003 and 0.012 respectively.(Table4) Multivariate analysis showed that PLWHIV who presented with Fever were over 3 times more likely to present at a late stage of the disease, compared to those without fever (P value= 0.025) and those with rashes were over 5-fold more likely to present as a late stage of the disease than those without rashes (P value = 0.025).(Table 5)  years.This age group may help to maintain HIV transmission in the society, since many may still be single and more likely to be sexually active, considering the fact that sexual intercourse was the most perceived route of transmission in the study by more than eighty percent of the respondents.
In the present study, out of the 81 respondents that were recently diagnosed (less than 1 month prior to the study), about 68% of them presented late.Seventy-one percent perceived they were ill at presentation, and this perception was a predictor for late presentation.It can be inferred that until PLWHIV perceived that they were ill, they would not access HIV screening service and that may explain why majority presented within one month of diagnosis.The implication of this is that the risk of transmission will be high within the population, much so when one considers the high prevalence of HIV in Akwa Ibom State.Though several studies have shown that patients presented late in developing countries, the proportion ranged from 40-55% depending on their definition of late 21,22,23 presentation.
Studies done in Lagos and Jos using CD4 below 350 cells/ml similar to this study, 18 reported prevalence of 67.4% and 85.6% 24 respectively , which were much higher than the 60.2% found in the present study.The mean CD4 among the late presenters of 178.1 +/-16.2 which was less than 200cells/ml, CD4 of less than 200 cells/ml has been described as 13 advanced HIV disease in 2007.CD4 is the numerical estimations of the level of immunity of the patients, the lower it is the more susceptible an 25 individual becomes to a wide range of infections.A study done in Jos showed that CD4 less than 200cells/ml was a predictor of morbidity and 26 mortality.The present study also showed that those with secondary level of education were about 5 fold more likely to present late compared to those with primary education, no other study was seen to show any relationship.One would expect that the higher the level of education the more the uptake of healthcare services, possibly at this level of education the respondents were more aware of the disease and more conscious of stigmatization.Socio demographic characteristics like age and sex did not affect the clinical stage of presentation of the respondents.This is in contrast to a study done in Northern Nigeria where male gender and those above 35 years were more likely to present late to 26 the clinic.At presentation, 76% of the respondents were symptomatic, and came with one or two complains.A study done in Cape Town reported nausea, pain and vomiting as the most frequently reported 27 symptoms while in the present study fever, cough and rashes were the topmost symptoms.Fever and rashes were strong predictors of late presentation among the respondents, this is supported by the fact that persistent fever of more than 30 days had been 13 described by WHO as AIDS defining.This study was limited by the fact that it depended on patients' self-reporting of symptoms, no detailed history taking was done to elucidate other symptoms the patients might have had at presentation, also, most factors such as socio economic and environmental factors associated with late presentation were not considered in this study.In conclusion, symptoms like fever and rashes were the predictors of late presentation of HIV in this setting.It is hoped that test and treat policy will help to reduce the high proportion of late presentation.This will be achieved with high level of awareness on screening at the community level.
2 at bivariate level Ethical consideration: Ethical clearance and approval were obtained from Ethical Review Committee of University of Uyo Teaching Hospital as well as the review committee of Akwa Ibom State Ministry of Health.

TABLE 2 : DISTRIBUTION OF RESPONDENTS ACCORDING TO THEIR SOCIO DEMOGRAPHIC CHARACTERISTICS AND CLINICAL STAGE OF PRESENTATION
*fischer's exact test +significant P value